Margaret Colin was born in Brooklyn, New York and raised on Long Island. She graduated from Baldwin Senior High School in 1976. Margaret began acting in The Edge of Night (1956) (her character was a heiress and former terrorist, with seven murder attempts), and was employed next on As the World Turns (1956), portraying character Margo Montgomery. Margaret's first film appearance were as a teacher in John Hughes's Pretty in Pink (1986), followed by a role in Jonathan Demme's Something Wild (1986), where she played Irene, girlfriend to Ray Liotta's character. The following year, she had supporting roles in Like Father Like Son (1987), and 3 Men and a Baby (1987). In film, Margaret either had minor, or supporting, roles; it's her work in television that perhaps makes her most memorable. Ms Colin continued acting with parts in Chicago Hope (1994), and The Wright Verdicts (1995). In 2000, Margaret earned a Saturn Award for Best Genre TV Actress for her role as Lisa Wiseman in the series Now and Again (1999). From 2007 to 2013, she played Eleanor Waldorf in the series Gossip Girl (2007).